产品货号：
Z11321
中文名称：
Aquaporin 4/AQP4抗体
英文名称：
Anti-Aquaporin 4/AQP4 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Aquaporin 4/AQP4 Antibody |
| 指标别名 | AQP 4;AQP4;aquaporin 4;NMO-IgG |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F |
| 基因名称 | AQP4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human Aquaporin 4 (295-323aa KPGVVHVIDVDRGEEKKGKDQSGEVLSSV),different from the related mouse sequence by two amino acids,and from the related rat sequence by three amino acids. |
| 实际分子量 | 35KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Aquaporin 4 is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells.The gene of AQP4 is mapped to 18q11.2-q12.1.Similar to other aquaporins,the AQP4 gene is composed of 4 exons encoding 127,55,27,and 92 amino acids separated by introns of 0.8,0.3,and 5.2kb.Unlike other aquaporins,an alternative coding initiation sequence (designated exon 0) was located 2.7kb upstream of exon 1.When spliced together,M1 and the subsequent 10 amino acids are encoded by exon 0;the next 11 amino acids and M23 are encoded by exon 1.AQP4 is expressed in astrocytes and is upregulated by direct insult to the central nervous system.And AQP4 is the predominant water channel in the brain and has an important role in brain water homeostasis.It is abundant in mammalian brain and is concentrated in astrocytic foot processes at the blood-brain barrier. |
| Uniprot ID | P55087 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | aquaporin 4 |
| 蛋白名全称 | Aquaporin-4 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section (IHC-F) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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